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TriGAN-SiaMT: A triple-segmentor adversarial network                                                                A systematic review of secure federated learning based on
              with bounding box priors  for semi-supervised brain lesion                                                                           blockchain and  Multi-Party computation

                                                 segmentation


                                                                                                                                                                              Author(s):

                                                       Author(s):
                                                                                                                               Bhutta, M. N. M. (Abu Dhabi University), Irtaza, G. (University of Education, Lahore), Mehmood, A. (Abu Dhabi University),
                                                                                                                               Hamood, R. (National University of Science and Technology), Makhdoom, I. (National University of Science and Technology),
        Alshurbaji, M. (Khalifa University of Science and Technology), Assefa, M. (Khalifa University of Science and Technology),
        Obeid, A. (Khalifa University of Science and Technology), Seghier, M. L. (Khalifa University of Science and Technology),                   Elhadef, M. (Abu Dhabi University), Rehman, M. H. U. (King’s College London)
        Hassan, T. (Abu Dhabi University), Taha, K. (Khalifa University of Science and Technology), Werghi, N. (Khalifa University of                                        Index Terms:
                                                  Science and Technology)

                                                                                                                               Artificial intelligence; Collaborative learning; Distributed computer systems; Information leakage; Learning
                                                     Index Terms:
                                                                                                                               algorithms; Learning systems; Privacy-preserving techniques; Block-chain; Blockchain-based decentralization;
                                                                                                                               Decentralisation; Decentralised; Decentralized trust mechanism; Federated learning security; Integrity verifications;
        Brain; Decision making; Image segmentation; Labeled data; Network architecture; Semi-supervised learning;
        Teaching; Bounding-box; Brain lesion segmentation; Brain lesions; Deep learning; Exponential moving averages;          Machine-learning; Model integrity verification; Privacy preserving; Privacy-preserving machine learning; Secure
                                 Lesion segmentations; Mean-teacher; Siamese; Teachers’                                                                   multi-party  computation;  Trust  mechanism;  Blockchain

                                                                                                                                                                               Abstract:
                                                        Abstract:

                                                                                                                               Federated Learning enables collaborative model training without compromising data privacy. However, security concerns
        Accurate brain lesion segmentation in MRI is critical for clinical decision-making, but pixel-wise annotations remain costly
        and time-consuming. We propose TriGAN-SiaMT, a novel semi-supervised segmentation framework that combines              remain, particularly regarding participant contributions and model integrity. This paper explores the potential of integrating
        adversarial learning, consistency regularization, and bounding box priors. Our architecture comprises three segmentors (   Blockchain and Multi-Party Computation techniques to address these challenges in Federated Learning. We systematically
        S 0, S 1, S 2) and two discriminators ( D 0, D 1). It includes: (1) a supervised branch ( S 0↔ D 0) trained on a small labeled   review recent research works on examining the capabilities of Blockchain-based Federated Learning and multi-party
        subset; (2) a Siamese branch ( S 1↔ D 1) with an identical architecture to S 0↔ D 0, but trained on unlabeled data; and (3) a   computation in mitigating security threats in federated learning, such as data leakage and model poisoning. In addition, by
        teacher branch ( S 2) updated via exponential moving average (EMA) from S 1, following the Mean Teacher (MT) paradigm.   analysing the convergence of these technologies, we aim to provide insights into their potential for building more secure,
        The teacher S 2 generates pseudo-labels to supervise S 1. It also provides soft segmentations to guide D 1, which does   trustworthy, and privacy-preserving Federated Learning. We conclude the review by identifying open research questions
        not see any labeled data. The model enforces consistency at multiple levels: between S 0 and S 1 (Siamese consistency),   and outlining promising directions for future research in this area, as this convergence is not only a technical achievement
        and between S 1 and S 2 (EMA consistency). Bounding box priors are incorporated as weak supervision for both labeled               but a foundational one towards democratised, secure, and privacy-aware artificial intelligence.
        and unlabeled images, improving lesion localization. Evaluated on the ISLES 2022 and BraTS 2019 datasets, TriGAN-SiaMT                                             Read the paper
        achieves DSC scores of 84.80 % and 86.32 %, respectively, using only 5 % labeled data. These results demonstrate strong
                       performance under limited supervision and robust generalization across brain lesions.


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